The historical marker for the Tullahassee Mission is located along US-69 in Tallahassee, one of the few surviving all-Black towns in Oklahoma. The Tullahassee Mission was a Presbyterian mission and school founded in the 1850s in the Creek Nation Indian Territory by a minister named Robert Loughridge.

The mission was originally built for the Musogee Creek students, however the children were transferred to another school after the building was burned in a fire.The Muscogee paid to rebuild the damaged building and gave it to the Creek Freedman and the school reopened as the Tullahassee Manual Labor School. After statehood, the federal government took over the property and sold it. In 1914, the African Methodist Episcopal Church bought the property for use as Flipper-Key-Davis College. At the time, this was the only institution in the state that offered higher education to Black Oklahomans.